Detalhe da pesquisa
1.
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.
Immunity
; 54(10): 2385-2398.e10, 2021 10 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34508662
2.
A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.
Am J Hum Genet
; 109(2): 328-344, 2022 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35077668
3.
A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing.
Nucleic Acids Res
; 49(7): e40, 2021 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33503245
4.
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.
Nature
; 538(7625): 388-391, 2016 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27723741
5.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30718425
6.
Current advances in microcell-mediated chromosome transfer technology and its applications.
Exp Cell Res
; 390(1): 111915, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32092294
7.
Transchromosomic technology for genomically humanized animals.
Exp Cell Res
; 390(2): 111914, 2020 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32142854
8.
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Int J Mol Sci
; 22(6)2021 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33799598
9.
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
BMC Biotechnol
; 20(1): 44, 2020 08 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32819341
10.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31455676
11.
Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.
Biochem Biophys Res Commun
; 508(2): 603-607, 2019 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30509488
12.
Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo.
Xenobiotica
; 49(11): 1303-1310, 2019 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-30561249
13.
Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.
J Hum Genet
; 63(2): 145-156, 2018 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-29180645
14.
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Drug Metab Dispos
; 46(11): 1756-1766, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-29777024
15.
Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.
Luminescence
; 33(3): 616-624, 2018 May.
Artigo
Inglês
| MEDLINE | ID: mdl-29424036
16.
Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.
BMC Biotechnol
; 17(1): 54, 2017 06 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28637431
17.
A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.
J Gene Med
; 18(10): 273-281, 2016 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-27591740
18.
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.
Haematologica
; 106(2): 635-640, 2021 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32354872
19.
A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.
Chromosome Res
; 23(1): 111-33, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25657031
20.
Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.
Biopharm Drug Dispos
; 37(1): 3-14, 2016 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26352195